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Amazon
LIVER SUPPORT*
120 capsules (600 mg each)
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A synergistic formula of 8 rainforest botanicals to nutritionally support liver function.* For more information on the individual ingredients in Amazon Liver Support, follow the links provided below to the plant database files in the Tropical Plant Database.
Each rainforest botanical in this professional formula has been sustainably harvested in the Amazon Rainforest. Click here to learn more about our rainforest ingredients and wild harvesting methods. This product contains no binders, fillers, or exipients and is 100% finely milled natural plants. This product is backed by Raintree's Unconditional Guarantee.
Ingredients: A proprietary blend of picão preto, carqueja, erva tostão, chanca piedra, boldo, gervâo, fedegoso, and artichoke. This formula is 100% pure natural ground plants. No binders, fillers or other additives are used. These plants have grown naturally in the richness of the Amazon without any pesticides or fertilizers.
Suggested Use: Take 3 capsules twice daily.
Contraindications: Not to be used during pregnancy or while breast-feeding.
Drug Interactions: None reported; however, based on animal studies, it may potentiate antihypertensive drugs.
Other Practitioner Observations:
- Several ingredients in the formula have been documented with liver detoxing effects in animal studies.* This may speed the clearance of some drugs metabolized in the liver (decrease the half-life), thereby reducing the pharmacological effect (and/or side effects) of certain drugs required to be metabolized in the liver.
- Several plants in this formula have been documented to reduce blood pressure in animal studies.* Individuals with low blood pressure should be monitored for this possible effect.
- Gervâo contains salicylic acid. Those allergic to aspirin or salicylates may wish to avoid this formula.
A 120 capsule bottle is $31.95 each
Or buy 3 bottles for $30.95 each
Or buy 6 bottles for $28.95 each
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Print a PDF Amazon Liver Support Brochure
Please note that this is a professional product offered by health practitioners and it is not available in retail stores. Click here to see a list of practitioners who use our products.
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Third-Party Published Research*
This proprietary Raintree product has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.
Picão Preto (Bidens pilosa)
Chin, H. W., et al. “The hepatoprotective effects of Taiwan folk medicine ‘ham-hong-chho’ in rats.” Am. J. Chin. Med. 1996; 24(3–4): 231–40.
Chiang, Y. M., et al. "Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator." J. Ethnopharmacol. 2006 Oct 19;
Yang, H. L., et al. "Protection from oxidative damage using Bidens pilosa extracts in normal human erythrocytes." Food Chem. Toxicol. 2006 Sep; 44(9): 1513-21.
Abajo, C., et al. “In vitro study of the antioxidant and immunomodulatory activity of aqueous infusion of Bidens pilosa.” J. Ethnopharmacol. 2004 Aug; 93(2-3): 319-23.
Chang, S. L., et al. “Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice.” Planta Med. 2004; 70(11):1045-51.
Chiang, Y. M., et al. “Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa.” J. Ethnopharmacol. 2004 Dec; 95(2-3): 409-19.
Usami, E., et al. “Assessment of antioxidant activity of natural compound by water- and lipid-soluble antioxidant factor” Yakugaku Zasshi. 2004; 124(11): 847-50.
Carqueja (Baccharis genistelloides, trimera)
Soicke, H., et al. “Characterisation of flavonoids from Baccharis trimera and their antihepatotoxic properties.” Planta Med. 1987; 53(1): 37–9.
Abad, M. J., et al. “Anti-inflammatory activity of four Bolivian Baccharis species (Compositae).” J. Ethnopharmacol. 2006 Feb; 103(3): 338-44.
Simoes-Pires, C. A., et al. "Isolation and on-line identification of antioxidant compounds from three Baccharis species by HPLC-UV-MS/MS with post-column derivatisation." Phytochem. Anal. 2005 Sep-Oct; 16(5): 307-14.
Gene, R. M., et al. “Anti-inflammatory and analgesic activity of Baccharis trimera: Identification of its active constituents.” Planta. Med. 1996; 62(3): 232–5.
Gene, R. M., et al. “Anti-inflammatory effect of aqueous extracts of three species of the genus Baccharis.” Planta Med. 1992 Dec; 58(6): 565-6.
Abad, M. J., et al. “Antiviral activity of Bolivian plant extracts.” Gen. Pharmacol. 1999; 32(4): 499–503.
Abad, M. J., et al. “Antiviral activity of some South American medicinal plants.” Phytother. Res. 1999 Mar; 13(2): 142-6.
Melo, S. F., et al. “Effect of the Cymbopogon citratus, Maytenus ilicifolia and Baccharis genistelloides extracts
against the stannous chloride oxidative damage in Escherichia coli.” Mutat. Res. 2001 Sep; 496(1-2): 33-8.
de las Heras, B., et al. “Antiinflammatory and antioxidant activity of plants used in traditional medicine in
Ecuador.” J. Ethnopharmacol. 1998 Jun; 61(2): 161-6.
Erva Tostão (Boerhaavia diffusa)
Rawat, A. K., et al. “Hepatoprotective activity of Boerhaavia diffusa L. roots—a popular Indian ethnomedicine." J.
Ethnopharmacol. 1997; 56(1): 61–66.
Chandan, B. K., et al. “Boerhaavia diffusa: a study of its hepatoprotective activity." J. Ethnopharmacol. 1991; 31(3):
299–307.
Sohni, Y. R., et al. “Activity of a crude extract formulation in experimental hepatic amoebiasis and in
immunomodulation studies. J. Ethnopharmacol. 1996 Nov; 54(2-3): 119-24.
Chanca Piedra (Phyllanthus niruri, amarus)
Stickel, F., et al. "Herbal medicine in the treatment of liver diseases." Dig. Liver Dis. 2007 Feb 27;
Bhattacharjee, R., et al. "Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties." Food Chem. Toxicol. 2006 Nov 11;
Chatterjee, M., et al. "Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo." Indian J. Biochem. Biophys. 2006 Oct; 43(5): 299-305.
Bhattacharjee, R., et al. "The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties." Phytother. Res. 2006; 20(7): 595-601.
Lee, C. Y., et al. "Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride." Am. J. Chin. Med. 2006; 34(3): 471-82.
Chatterjee, M., et al. "Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress." Pathophysiology. 2006 May; 13(2): 95-102.
Khatoon, S., et al. “Comparative pharmacognostic studies of three Phyllanthus species.” J. Ethnopharmacol. 2006 Mar; 104(1-2): 79-86.
Levy, C., et al. “Use of herbal supplements for chronic liver disease.” Clin. Gastroenterol Hepatol. 2004; 2(11): 947-56.
Rajeshkumar, N. V., et al. “Phyllanthus amarus extract administration increases the life span of rats with hepatocellular carcinoma.” J. Ethnopharmacol. 2000 Nov; 73(1–2): 215–19.
Padma, P., et al. "Protective effect of Phyllanthus fraternus against carbon tetrachloride-induced mitochondrial dysfunction." Life Sci. 1999; 64(25): 2411-17.
Jeena, K. J., et al. “Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on n-nitrosodiethylamine induced hepatocarcinogenesis.” Cancer Lett. 1999; 136(1): 11–16.
Thabrew, M. R., et al. “Phytogenic agents in the therapy of liver disease.” Phytother. Res. 1996; 10(6): 461–67.
Prakash, A., et al. “Comparative hepatoprotective activity of three Phyllanthus species, P. urinaria, P. niruri and P.simplex, on carbon tetrachloride induced liver injury in the rat.” Phytother. Res. 1995; 9(8): 594–96.
Dhir, H., et al. “Protection afforded by aqueous extracts of Phyllanthus species against cytotoxicity induced by lead and aluminium salts.” Phytother. Res. 1990; 4(5): 172–76.
Sreenivasa, R. Y. “Experimental production of liver damage and its protection with Phyllanthus niruri and Capparis spinosa (both ingredients of LIV52) in white albino rats.” Probe 1985; 24(2): 117–19.
Syamasundar, K. V., et al. "Antihepatotoxic principles of Phyllanthus niruri herbs." J. Ethnopharmacol. 1985; 14(1): 41-4.
Boldo (Peumus boldus)
Kringstein, P., et al. “Boldine prevents human liver microsomal lipid peroxidation
and inactivation of cytochrome P4502E1.” Free Radic. Biol. Med. 1995; 18(3): 559–63.
Cederbaum, A. I., et al. “Inhibition of rat liver microsomal lipid peroxidation by boldine.” Biochem, Pharmacol. 1992 Nov; 44(9): 1765-72.
Lanhers, M. C., et al. “Hepatoprotective and anti-inflammatory effects of a traditional medicinal plant of Chile, Peumus boldus.” Planta Med. 1991; 57(2): 110–15.
Kubinova, R., et al. “Chemoprotective activity of boldine: modulation of drug-metabolizing enzymes.” Pharmazie. 2001; 56(3): 242–43.
Jimenez, I., et al. “Biological disposition of boldine: in vitro and in vivo studies.” Phytother. Res. 2000 Jun; 14(4): 254-60.
Jang, Y. Y., et al. “Protective effect of boldine on oxidative mitochondrial damage in streptozotocin-induced diabetic rats.” Pharmacol. Res. 2000; 42(4): 361–71.
Bannach, R., et al. “Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes.” Cell Biol. Toxicol. 1996 Apr; 12(2): 89-100.
Gervâo (Stachytarpheta jamaicensis)
Park, J. C., et al. “Effects of methanol extract of Cirsium japonicum var. Ussuriense and its principle, hispidulin-7-O-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats.” Phytother. Res. 2004; 18(1): 19-24.
Xiong, Q., et al. “Acteoside inhibits apoptosis in D-galactosamine and lipopolysaccharide-induced liver injury.” Life Sci. 1999; 65(4): 421–30.
Xiong, Q., et al. “Hepatoprotective activity of phenylethanoids from Cistanche deserticola.” Planta Med. 1998; 64(2): 120–25.
Ferrandiz, M. L., et al. “Hispidulin protection against hepatotoxicity induced by bromobenzene in mice.” Life Sci. 1994; 55(8): PL145–50.
Fedegoso (Cassia occidentalis)
Jafri, M. A., et al. “Hepatoprotective activity of leaves of Cassia occidentalis against paracetamol and ethyl alcohol intoxication in rats.” J. Ethnopharmacol. 1999; 66(3): 355–61.
Sharma, N., et al. “Protective effect of Cassia occidentalis extract on chemical-induced chromosomal aberrations in mice.” Drug Chem. Toxicol. 1999; 22(4): 643–53.
Saraf, S., et al. “Antiheptatotoxic activity of Cassia occidentalis.” Int. J. Pharmacog. 1994; 32(2): 178–83.
Subbarao, V. V., et al. “Changes in serum transaminases due to hepatotoxicity and the role of an indigenous hepatotonic, LIV-52.” Probe 1978; 17(2): 175–78.
Sethi, J. P., et al. “Clinical management of severe acute hepatic failure with special reference to LIV-52 in therapy.” Probe 1978; 17(2): 155–58.
Sama, S., et al. “Efficacy of an indigenous compound preparation (LIV-52) in acute viral hepatitis—A double blind study.” Indian J. Med. Res. 1976; 64: 738.
Artichoke (Cynara scolymus)
Glasl, S., et al. "Choleretic effects of the Mongolian medicinal plant Saussurea amara in the isolated perfused rat liver." Planta Med. 2007; 73(1): 59-66.
Speroni, E., et al. “Efficacy of different Cynara scolymus preparations on liver complaints.” J. Ethnopharmacol. 2003 Jun; 86(2-3): 203-11.
Betancor-Fernandez, A., et al. “Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity.” J. Pharm. Pharmacol. 2003; 55(7): 981-6.
Gebhardt, R. “Prevention of taurolithate-induced hepatic bile canalicular distortions by HPLC-characterized extracts of artichoke (Cynara scolymus) leaves.” Planta Med. 2002; 68(9): 776–79.
Aktay, G., et al. “Hepatoprotective effects of Turkish folk remedies on experimental liver injury.” J. Ethnopharmacol. 2000 Nov; 73(1-2): 121-9.
Adzet, T., et al. “Hepatoprotective activity of polyphenolic compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes.” J. Nat. Prod. 1987; 50(4): 612–17.
Maros, T., et al. “Effects of Cynara scolymus extracts on the regeneration of rat liver. 1.” Arzneimittelforschung 1966; 16(2): 127–29.
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* The statements contained herein have not been evaluated
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not intended to treat, cure, mitigate or prevent any disease.
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Last updated 3-20-2010
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